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Prothrombin complex concentrate
Prothrombin complex concentrate (PCC, trade names Beriplex, Octaplex,〔 Kcentra, Cofact, among others) is a combination of blood clotting factors II, VII, IX and X, as well as protein C and S,〔(FASS.se (Farmaceutiska Specialiteter i Sverige - the Swedish official drug catalog) > Ocplex ) Last updated: 2009–09–03〕 prepared from fresh-frozen human blood plasma. It is used to reverse the effects of oral anticoagulation therapy when bleeding occurs (e.g. in the brain or gut) requiring rapid action to accelerate coagulation.
PCC is effective but expensive. In the UK, it is prescribed in discussion with a haematologist. It is available as a powder and solvent for solution for injection.
==Indications==
PCC reverses the effects of warfarin and other coumarin anti-coagulants and is used in cases of significant bleeding in patients with a coagulopathy (INR > 8.0, prolonged prothrombin time). It is also used when such a patient must undergo an emergency operation treatment. Other indications include a deficiency of one of the included clotting factors, either congenital or due to liver disease, and hemophilia.
Several guidelines, including American College of Chest Physicians,〔(【引用サイトリンク】url=http://journal.publications.chestnet.org/article.aspx?articleid=1159453 )〕 recommend PCC for warfarin reversal in patients with serious bleed.〔Haemostasis and Thrombosis Task Force for the British Committee for Standards in Haematology. Guidelines on oral anticoagulation: 3rd edition. Br J Haematol. 1998;101:374-387.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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